We use high-tec recombinant engineering, structural biology, reverse genetics, biochemistry, cell-free protein synthesis techniques, cell imaging and applied immunology to unravel the virus life cycle, step by step. We have developed powerful experimental systems for examining viral protein expression, RNA synthesis, virion assembly and virus-host interactions. More recently, those learned techniques have been applied to the related species of human rhinoviruses, with particular attention to the recently discovered RV-C species. We used this system to examine molecular questions about picornavirus translation, proteolytic processing, morphogenesis and pathogenicity. Previous focus in the lab centered the relationship of the cardiovirus genus to other members of the picornavirus family and the unique features of the cardioviruses. We are interested in all aspects of RNA virology and in bioinformatics methods for viral genomics. Molecular biology of RNA picornaviruses protein translation, proteolytic processing RNA replication viral pathogenesis viral vaccines bioinformatics comparative proteomics, sequence analysis computer-assisted RNA structure determinations.
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